eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2006   Volume No 12 – pages 1-15

Title: Biochemical modification of titanium surfaces: Peptides and eCM proteins

Author: M Morra

Address: Nobil Bio Ricerche, Str. S. Rocco 36, 14018 Villafranca d'Asti, Italy

E-mail: mmorra at

Key Words: Titanium implants, surface modification, surface analysis, peptides, eCM proteins, collagen.

Publication date: July 24th 2006

Abstract: This paper reviews current approaches to the enhancement of bone regeneration at the interface with implant devices, by immobilization of biomolecules to titanium surfaces. In particular, techniques based on surface linking of peptides or extracellular matrix (eCM) proteins are reviewed, trying to describe surface modification approaches and to present results of chemico-physical and biological evaluations, both in vitro and in vivo. Based on existing literature, surface modification by peptides or eCM proteins appears as an effective way to stimulate bone regeneration over that provided by titanium, as suggested by basic studies and in vitro results and confirmed by in vivo findings.

Article download: Pages 1-15 (PDF file)
DOI: 10.22203/eCM.v012a01