eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2009   Volume No 18 – pages 40-48

Title: Tissue reaction to implants of different metals: A study using guide wires in cannulated screws

Authors: DM Devine, M Leitner, SM Perren, LP Boure, SG Pearce

Address: AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos, Switzerland

E-mail: declan.devine at

Key Words: Animal model, bone, cobalt alloy, stainless steel, corrosion

Publication date: October 20th 2009

Abstract: Cannulated screws, along with guide wires, are typically used for surgical fracture treatment in cancellous bone. Breakage or bending deformation of the guide wire is a clinical concern. Mechanically superior guide wires made of Co-Cr alloys such as MP35N and L605 may reduce the occurrence of mechanical failures when used in combination with conventional (316L stainless steel) cannulated screws. However the possibility of galvanic or crevice corrosion and adverse tissue reaction, exists when using dissimilar materials, particularly in the event that a guide wire breaks, and remains in situ. Therefore, we designed an experiment to determine the tissue reaction to such an in vivo environment. Implant devices were designed to replicate a clinical situation where dissimilar metals can form a galvanic couple. Histological and SEM analyses were used to evaluate tissue response and corrosion of the implants. In this experiment, no adverse in vivo effects were detected from the use of dissimilar materials in a model of a broken guide wire in a cannulated screw.

Article download: Pages 40-48 (PDF file)
DOI: 10.22203/eCM.v018a04