eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2010   Volume No 19 – pages 193-204

Title: Aligned electrospun polymer fibres for skeletal muscle regeneration

Author: KJ Aviss, JE Gough, S Downes

Address:School of Materials, Biomaterials Group, The University of Manchester, Manchester, M1 7HS, UK

E-mail: sandra.downes at manchester.ac.uk

Key Words: Electrospinning, myoblasts, alignment, PLGA, surface topography.

Publication date: May 13th 2010

Abstract: Skeletal muscle repair is often overlooked in surgical procedures and in serious burn victims. Creating a tissue-engineered skeletal muscle would not only provide a grafting material for these clinical situations, but could also be used as a valuable true-to-life research tool into diseases affecting muscle tissue. Electrospinning of the elastomer PLGA produced aligned fibres that had the correct topology to provide contact guidance for myoblast elongation and alignment. In addition, the electrospun scaffold required no surface modifications or incorporation of biologic material for adhesion, elongation, and differentiation of C2C12 murine myoblasts.

Article download: Pages 193-204 (PDF file)
DOI: 10.22203/eCM.v019a19