2013 Volume No 25 pages 190-203
Title: Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation |
Author: NYC Yu, A Schindeler, L Peacock, K Mikulec, J Fitzpatrick, AJ Ruys, JJ Cooper-White, DG Little |
Address: Orthopaedic Research & Biotechnology, Research Building, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia |
E-mail: nicole.yu at sydney.edu.au or: aaron.schindeler at sydney.edu.au |
Key Words: Zoledronic acid; bisphosphonate; rhBMP-2; bone morphogenetic protein; bone tissue engineering; biodegradable polymer scaffold; thermally induced phase separation. |
Publication date: February 27th 2013 |
Abstract: We describe two studies encompassing the iterative refinement of a polymer-based rhBMP-2 delivery system for bone tissue engineering. Firstly, we compared the bone-forming capacity of porous poly(D,L-lactic-co-glycolic acid) (PLGA) scaffolds produced by thermally induced phase separation (TIPS) with non-porous solvent cast poly(D,L-lactic acid) (PDLLA) used previously. Secondly, we examined the potential synergy between rhBMP-2 and local bisphosphonate in the PLGA scaffold system. |
Article download: Pages
190-203 (PDF file) |