2014 Volume No 27 – pages 196-212
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Title: A systematic review of animal models for Staphylococcus aureus osteomyelitis |
Author: W Reizner, JG Hunter, NT O’Malley, RD Southgate, EM Schwarz, SL Kates |
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Address: 601 Elmwood Ave, Box 665, Rochester, NY 14642, USA |
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E-mail: Stephen_Kates at urmc.rochester.edu |
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Key Words: Osteomyelitis, animal models, methicillin-resistant Staphylococcus aureus (MRSA), infection, fracture, implant. |
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Publication date: March 25th 2014 |
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Abstract: Staphylococcus aureus (S. aureus) osteomyelitis is a significant complication for orthopaedic patients undergoing surgery, particularly with fracture fixation and arthroplasty. Given the difficulty in studying S. aureus infections in human subjects, animal models serve an integral role in exploring the pathogenesis of osteomyelitis, and aid in determining the efficacy of prophylactic and therapeutic treatments. Animal models should mimic the clinical scenarios seen in patients as closely as possible to permit the experimental results to be translated to the corresponding clinical care. To help understand existing animal models of S. aureus, we conducted a systematic search of PubMed and Ovid MEDLINE to identify in vivo animal experiments that have investigated the management of S. aureus osteomyelitis in the context of fractures and metallic implants. In this review, experimental studies are categorised by animal species and are further classified by the setting of the infection. Study methods are summarised and the relevant advantages and disadvantages of each species and model are discussed. While no ideal animal model exists, the understanding of a model’s strengths and limitations should assist clinicians and researchers to appropriately select an animal model to translate the conclusions to the clinical setting. |
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Article download: Pages
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