eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2016   Volume No 31 – pages 355-381

Title: Delivery of pharmaceutics to bone: nanotechnologies, high-throughput processing and in silico mathematical models

Authors: IS Alencastre, DM Sousa, CJ Alves, L Leitão, E Neto, P Aguiar, M Lamghari

Address: I3S/INEB, Rua Alfredo Allen, 208, 4220-135 Porto, Portugal

E-mail: lamghari at

Key Words: Bone tissue engineering, targeted drug delivery strategies, biomaterials, high-throughput processing technology, in silico tools, nanotechnology.

Publication date: May 27th 2016

Abstract: In the last decade, nanobiotechnology research has emerged as a revolutionising new approach to the 21st century pharmaceutical challenges, offering valuable gains in a vast set of biomedical applications. In the field of bone tissue engineering, a broad range of nanotechnology-based delivery systems have been researched and the most recent developments in high-throughput technology and in silico approaches are creating very high expectations.
This review presents a comprehensive overview of the emergent nanotechnology-based materials, processing techniques and research strategies for the delivery of pharmaceutics to bone including the materials general characteristics and the available drug delivery systems to distribute agents systemically or locally. Complementary to what was stated above, it also reviews the latest high-throughput processing techniques and the existent in silico tools (mathematical and computational models) used to help on the design of delivery systems.

Article download: Pages 355-381 (PDF file)
DOI: 10.22203/eCM.v031a23