2006 Volume No 12 – pages 92-101
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Title: The structure and function of cartilage proteoglycans |
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Author: PJ Roughley |
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Address: Genetics Unit, Shriners Hospital for Children
and Department of Surgery, McGill University, Montreal, Quebec,
Canada
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E-mail: proughley at shriners.mcgill.ca
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Key Words: Proteoglycan, aggrecan, link protein,
hyaluronan, decorin, biglycan, fibromodulin, lumican, cartilage.
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Publication date: November 30th 2006 |
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Abstract: Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains. This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function. |
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Article download: Pages
92-101 (PDF file) |
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