eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2020   Volume No 40 – pages 1-20

Title: The current state of PEEK implant osseointegration and future perspectives: a systematic review

Authors: N AlOtaibi, K Naudi, D Conway, A Ayoub

Address: University of Glasgow, Glasgow University Dental Hospital and School/Oral and Maxillofacial Surgery, Glasgow, UK

E-mail: ashraf.ayoub at

Abstract: Polyetheretherketone (PEEK) has been considered as an alternative to replace surgical metal implants. Several medical applications, including dental and orthopaedic implants, need confirmed osseointegration before functional loading. The present study aims at providing a comprehensive systematic review of the evidence on PEEK implants' osseointegration. A systematic search was conducted using Cochrane library, MEDLINE (PubMed), Ovid MEDLINE, Web of Science and EMBASE databases. Publications were identified in accordance with specific inclusion and exclusion criteria. Eligibility screening, data extraction and quality assessment were performed. The review protocol was registered in PROSPERO (CRD42018116061). A total of 55 articles were reviewed and 29 of the most relevant that met the inclusion criteria were selected. Heterogeneity was identified among the included studies.
     Several approaches have been applied to enhance PEEK osseointegration, with most in vivo studies conducted on small-scale animal models but no study evaluating the osseointegration of PEEK under cyclic loading. However, PEEK modifications are demonstrated to enhance osseointegration preclinically. Collectively, the present review shows a shortage of evidence, including a lack of comprehensive assessment of osseointegration, the need for large-animal-model tests, the need to assess the effect of loading on the implants and the lack of randomised controlled clinical trials.

Key Words: Polyetheretherketone, dental implant, coated polyetheretherketone, biomaterials, synthetic polymers, osseointegration, polyetheretherketone composite.

Publication date: July 15th 2020

Article download: Pages 1-20 (PDF file)

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