2021 Volume No 41 – pages 31-39
Title: Cell therapy for medication-related osteonecrosis of the jaw: update on treatment strategies |
Authors: N Kaibuchi, T Iwata, T Okamoto, Y Kawase-Koga, M Yamato |
Address: Department of
Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
(TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan |
E-mail: iwata.peri at tmd.ac.jp |
Abstract: Despite extensive research since the first report of medication-related osteonecrosis of the jaw (MRONJ)
in 2003, the optimal treatment and preventive modalities for the condition are not clear. Therefore, its
management has been a concern in dentistry, oral and maxillofacial surgery, as well as departments involved
in the treatment of cancers and/or bone diseases worldwide. Several cases of MRONJ could not be cured
by conventional treatment strategies, as per the recommendations in various position papers. Therefore, a
number of studies, including randomized controlled trials, have been conducted to examine the efficacy of
novel therapies. However, no definite treatment modality has been determined. Several types of cell therapies
have been documented. 10 animal studies and 5 case reports have been documented, in which autologous
transplantation of cells has been carried out in MRONJ patients. Although these reports showed the efficacy of
cell therapy, they were not large-scale, statistically accurate clinical studies; hence, the efficacy of cell therapy
for this condition is not certain. However, the efficacy of MRONJ treatment using mesenchymal stromal
cell (MSC) sheets has been investigated since 2013. This has been confirmed through various experiments
in which MSC sheets were transplanted into model rats and beagle dogs exhibiting MRONJ-like lesions.
Based on these results, a clinical study of MRONJ treatment using periodontal ligament-derived MSC sheets
is being currently planned. |
Key Words: Bisphosphonate, anti-resorptive agents, anti-receptor activator of NFκβ ligand antibody,
denosumab, anti-cancer agents, osteonecrosis of the jaw, cell therapy, cytotherapy, regenerative therapy,
cell sheet. |
Publication date: January 5th 2021 |
Article download: Pages
31-39 (PDF file) |
