eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2021   Volume No 41 – pages 52-72

Title: Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology

Authors: J Melrose, S Tessier, MV Risbud

Address: Department of Orthopaedic Surgery, Thomas Jefferson University, 1025 Walnut Street, Suite 501 College Bldg., Philadelphia, PA 19107, USA.

E-mail: makarand.risbud at

Abstract: Disc degeneration and associated back and neck pain elicits a substantial burden on healthcare systems and the individuals affected, necessitating the development of novel therapeutic strategies. This goal can only be achieved by a better understanding of intervertebral disc development, homeostasis and pathogenesis. A number of genetic and in-bred murine models are reviewed to underscore the importance of the mouse as an animal model of choice for the assessment of intervertebral disc pathobiology. Appraisals of the differences between mouse and human musculoskeletal systems and proteoglycan structures are also included. A number of important target pathways and molecules have been identified, many of which are worthy of further examination, requiring that the activity of these be confirmed in large animal models and assessed in the context of therapeutic intervention.

Key Words: Murine model, intervertebral disc, nucleus pulposus, annulus fibrosus, spine.

Publication date: January 12th 2021

Article download: Pages 52-72 (PDF file)

Twitter Facebook Google LinkedIn Print