eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2021   Volume No 41 – pages 811-833

Title: What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

Authors: M Matoug-Elwerfelli, H Nazzal, M Duggal, R El-Gendy

Address: Department of Clinical Dental Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia

E-mail: mmelwerfelli at

Abstract: Regenerative/revitalisation endodontic techniques are increasingly used as a treatment approach for the management of immature permanent teeth with necrotic pulps. Different chemical irrigants and medicaments are routinely used clinically for intra-canal disinfection. However, despite remarkable progress in this field, coronal discolouration, cell cytotoxicity, difficulty of removal of organic biofilm from the root canal, development of sensitisation and antimicrobial resistance are still challenges to this line of treatment. This review critically discusses and challenges the current status quo of antimicrobials used in regenerative endodontics and sheds the light on future alternative antimicrobial materials with regenerative potential.

Key Words: Antimicrobials, antibiotics, disinfection, biomaterials, regenerative endodontics, drug delivery, dental pulp stem cells, pulp regeneration.

Publication date: June 25th 2021

Article download: Pages 811-833 (PDF file)

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