eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2021   Volume No 42 – pages 375-391

Title: Tendon mechanobiology in small-animal experiments during post-transection healing

Authors: T Notermans, M Hammerman, P Eliasson, H Isaksson

Address: Department of Biomedical Engineering, Lund University, Box 118, 22100 Lund, Sweden.

E-mail: hanna.isaksson at

Abstract: Ruptures to tendons are common and costly, and no clinical consensus exists on the appropriate treatment and rehabilitation regimen to promote their healing as well as full recovery of functionality. Although mechanobiology is known to play an important role in tendon regeneration, the understanding of how mechano-regulated processes affect tendon healing needs further clarification. Many small-animal studies, particularly in rats and mice, have characterized the progression of healing in terms of geometrical, structural, compositional, mechanical, and cellular properties. Some of the properties are also studied under different mechanical loading regimens. The focus of this review is to summarize and generalize the information in the literature regarding spatial and temporal differentiation of tendon properties during rodent tendon healing following full-tendon transection, as well as how this is affected by altered in vivo loading regimens.

Key Words: Collagen, extracellular matrix, rupture, Achilles tendon, cells, unloading, immobilization, tissue differentiation, mechanical, heterogeneous.

Publication date: November 2nd 2021

Article download: Pages 375-391 (PDF file)

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