eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2021   Volume No 42 – pages 392-400

Title: Dentine matrix metalloproteinases as potential mediators of dentine regeneration

Authors: E Guirado, A George

Address: Department of Oral Biology, University of Illinois at Chicago College of Dentistry, Chicago, USA

E-mail: anneg at

Abstract: Matrix metalloproteinases (MMPs) have been implicated not only in the regulation of developmental processes but also in the release of biologically active molecules and in the modulation of repair during tertiary dentine formation. Although efforts to preserve dentine have focused on inhibiting the activity of these proteases, their function is much more complex and necessary for dentine repair than expected. The present review explores the role of MMPs as bioactive components of the dentine matrix involved in dentine formation, repair and regeneration. Special consideration is given to the mechanical properties of dentine, including those of reactionary and reparative dentine, and the known roles of MMPs in their formation. MMPs are critical components of the dentine matrix and should be considered as important candidates in dentine regeneration.

Key Words: Dentine, enamel, periodontal ligament, tooth, dental regenerative repair, matrix metalloproteinases, dental physiology, signalling molecules/growth factors.

Publication date: November 24th 2021

Article download: Pages 392-400 (PDF file)

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