eCM (Eur Cell Mater / e Cells & Materials) eCM Open Access Scientific Journal
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2023   Volume No 45 – pages 131-142

Title: Scaffold-based tissue engineering strategies for temporomandibular joint disc regeneration and replacement

Authors:  N Jiang, J Zhang, Z Li, SS Zhu

Address: State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease and West China Hospital of Stomatology, Sichuan University, Chengdu, China

E-mail: zss_1977 at

Abstract: The temporomandibular joint (TMJ) disc is a fibrocartilage tissue located between the mandibular condyle and the glenoid eminence, which is central to the TMJ functions. The TMJ disc is susceptible to irreparable degenerative changes or post-traumatic injuries, which can lead to the development of a disc-related disease. Scaffold-based tissue engineering offers the potential for regeneration and replacement of the damaged TMJ disc. The present review describes the biomaterials and manufacturing technologies used in scaffold-based TMJ disc engineering strategies and comprehensively evaluates the advantages and disadvantages of each strategy. As an understanding of the extracellular matrix (ECM) is fundamental for succesful TMJ disc tissue engineering, this review defines the key properties and roles of the TMJ disc ECM. Compared with the natural disc, the mechanical properties of the tissue-engineered TMJ disc are not satisfactory. Additionally, the in vivo durability of engineered discs and their long-term impact on the entire TMJ remain to be studied, especially in large-animal preclinical trials.

Keywords: Temporomandibular joint, temporomandibular joint disc, osteoarthritis, tissue engineering, scaffold, regeneration, replacement

Publication date: July 4th 2023

Article download: Pages 131-142 (PDF file)

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