eCM (Eur Cell Mater / e Cells & Materials) eCM Open Access Scientific Journal
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2024   Volume No 47 – pages 51-58

Title: Burn-synovectomy mouse model for temporomandibular joint osteoarthritis

Authors:  Ginny Ching-Yun Hsu

Address: Department of Orthodontics, Oregon Health and Science University, Robertson Life Sciences Building, Room 5N018, 2730 S Moody Ave, Portland OR 97209, USA

E-mail: hsug at

Abstract: Temporomandibular joint osteoarthritis (TMJ OA) occurs in 8 to 16 % of the population. Currently available animal models do not faithfully simulate the native disease progression of TMJ OA. The initiation of TMJ OA requires both local trauma and extended inflammation. In this study, we present a novel mouse model that reproduces these two conditions. This is achieved by a procedure involving both synovectomy (local trauma) and a distant burn injury (systemic inflammation). Its efficacy at inducing TMJ OA was assessed by histomorphologic and radiographic evaluation at 1, 3, and 9 weeks after the procedure. Burn-synovectomy mice exhibited significantly more degenerative hard and soft tissue changes in the TMJ than uninjured control or synovotomy mice. The observed histology in burn-synovectomy mice faithfully mimicked synovitis-induced TMJ OA progression. This animal model is invaluable in future research of the mechanism and risk factors of TMJ OA.

Keywords: Temporomandibular joint osteoarthritis, mouse model, temporomandibular disorders.

Publication date: March 5th 2024

Copyright policy: © 2024 The Author(s). Published by Forum Multimedia Publishing, LLC. This article is distributed in accordance with Creative Commons Attribution Licence (

Article download: Pages 51-58 (PDF file)

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