2025 Volume No 50 – pages 33-67
Title: Innovative immunomodulatory strategies in the management of peri-implantitis: current paradigms and future directions |
Authors: Y Wang, YD Lu, J Kang, LY Liu, X Liu, HH Liu |
Address: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041 Chengdu, Sichuan, China |
E-mail: hanghangliu_hx at foxmail.com |
Abstract: As dental implant technology becomes increasingly widespread, peri-implantitis induced bone resorption and implant loss have garnered significant academic attention. Current clinical treatments for peri-implantitis primarily focus on plaque control, but the limitations of traditional therapies often hinder effective outcomes. Treatment strategies targeting immune responses that can eliminate inflammation, control osteolytic environments, and restore physiological bone formation are promising approaches. This article comprehensively reviews the role of the immune system in the pathogenesis and progression of peri-implantitis through a synthesis of multiple literature sources. It introduces current immunomodulatory strategies in the treatment of peri-implantitis and discusses the potential applications and challenges of novel immunotherapies, including gene therapy, cell engineering, and nanotechnology, in the management of peri-implantitis. The aim is to provide guidance for translating immunotherapies from the laboratory to clinical practice. |
Keywords: Immunomodulation, peri-implantitis, inflammation, bone resorption, osteogenesis. |
Publication date: 8th April 2025 |
Copyright policy: © 2025 The Author(s). Published by Forum Multimedia Publishing, LLC. This article is distributed in accordance with Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/). |
Article download: Pages 33-67 (PDF file) |
