eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

Temporo-mandibular joint (TMJ) Special Issue

The temporo-mandibular joint (TMJ) is a synovial, ginglymoarthrodial joint between the mandibular condyle and the articular eminence of the temporal bone.  Among mammalian joints, the TMJ is unique because of its complex evolutionary origin from a Meckel’s cartilage scaffold, its fibrocartilaginous articular surface and its unique function as a sliding hinge joint.  Among medical practitioners, the TMJ is also unique because of the multitude and complexity of the disorders (TMDs) associated with the TMJ and the difficulties treating them.  Chronic TMD pain is a debilitating condition, frequently associated with elevated levels of suicidal ideation, depression and anxiety.  In recent history, TMD patients have been frequently subjected to orthodontic treatment, correction of malocclusion or orthognathic surgery, resulting in little therapeutic success.  In addition, surgical replacement and dissectomies have often not fulfilled patients’ expectations.  As a result, there is an enormous need for effective treatment modalities that will make a significant difference in the lives of patients suffering from chronic pain.  The unique developmental history of the TMJ and the complex etiology of TMDs necessitates the use of multiple model systems and therapeutic approaches.  The present Special Issue seeks to characterise some of these model systems, uncover the molecular mechanisms contributing the TMDs as well as identify and examine therapeutic approaches to offset the deleterious effects of TMJ disease.

Keywords: Temporo-mandibular joint, temporo-mandibular disorders, synovial membrane, synovial fluid, fibrocartilage.

Submission deadline: 30th of June 2022

All papers (invited and open submitted) undergo full peer review. All accepted manuscripts will receive a 25% discount on the Article Processing Charge (APC), i.e. 750CHF instead of 1000CHF.

Publication: immediately upon acceptance

Submit now

Editorial team

Richards_R_Geoff

eCM Scientific Editor

Prof. Brian Johnstone
Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon, US

 

Brian Johnstone, PhD, FIOR, FORS, is one of the Scientific Editors of the ECM journal, joining the board in 2004. He did his predoctoral research in England and postdoctoral studies in the USA where he is now the Research Director for the Department of Orthopaedics and Rehabilitation at Oregon Health & Science University. His main research area is skeletal tissue regeneration, and has worked on cartilage, spine, meniscus and temporomandibular disc. He developed and patented the system for the chondrogenic induction of stem cells. He has produced peer-reviewed manuscripts, chapters and reviews (13,204 citations, h-index of 48, i10-index of 72), with grants from numerous sources including NIH, Arthritis Foundation and Shriners Hospitals. Brian is a Past-President of the Orthopaedic Research Society and has served/serves on numerous grant review panels of national and international organizations and journal editorial boards. He currently advises the AO Research Institute, the Translational Medicine Institute at CSU, the Orthopaedic Research and Education Foundation and is the Mercator Fellow for a German multi-center program. Brian has received numerous national and international honors including being elected into the inaugural class of Fellows of International Orthopaedic Research (FIOR), and that of the Orthopaedic Research Society Fellows (FORS). He is now Chair of the College of FIORS. In 2017 he was awarded the Marshall R. Urist Award for his contributions to tissue regeneration research.

 

Richards_R_Geoff

eCM Scientific Editor

Prof. Thimios Mitsiadis
Orofacial Development & Regeneration, Institute of Oral Biology, University of Zurich, Zurich, CH

 

Thimios Mitsiadis is a dentist specialised in paediatric dentistry and Professor of Oral Biology at the Medical Faculty of the University of Zurich, Switzerland since 2006. He obtained a DDS degree from the Dental Faculty of the Kapodistrion, University of Athens (Greece), a Master degree in Immunology, Genetics and Differentiation, and a PhD in Developmental Biology from the University of Lyon (France). He conducted postdoctoral studies at the University of Helsinki (Finland), Karolinksa Nobel Institute (Sweden) and Yale University (USA). Previously, he was Professor at the Mediterranean University (France), Visiting Professor at the Ecole Normale Superieure of Lyon (France), Clinical Senior Lecturer at King's College London (UK), Visiting Professor at the Polytechnic University of Marche (Italy), Visiting Professor at the Second University of Napoli (Italy). Currently, he is Visiting Professor at the D’Annunzio University of Chieti-Pescara (Italy). Thimios conducts research in the fields of stem cells, genetics and molecular and experimental biology related to orofacial developmental and regeneration processes. He authored more than 160 papers in journals such as “Journal of Cell Biology”, “Development”, “Developmental Biology”, “Nature Genetics”, “Nature Cell Biology”, “Science Signaling”, “Scientific Reports”, “Cells”, “European Cells & Materials”, “Frontiers in Physiology” and gave more than 200 keynote and invited lectures. Thimios is an eCM Scientific Editor, has 7300 citations according to Google Scholar (5.200 according to Clarivate Analytics) and an H-index of 50 according to Google Scholar (41 according to Clarivate Analytics).

 

Richards_R_Geoff

eCM Guest Editor

Prof. Di Chen
Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Shenzhen, China

 

Di Chen, PhD, is a Chair Professor at the Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology (2020-present).  He was a tenure and endowed professor and Chairman of Department of Biochemistry at Rush University, Chicago (2011-2019). He is a member of ASBMR, ORS, OARSI and ICMRS. His major research interests include Osteoarthritis, Ankylosing Spondylitis and Genetic Bone Diseases. He has published 260 SCI papers with cumulative impact factor: 1783, citations: 24,470 and H-index: 78.

 

Richards_R_Geoff

eCM Guest Editor

Thomas G.H. Diekwisch
Center for Craniofacial Research and Diagnosis (CCRD) and Department of Periodontics, Texas A&M University College of Dentistry, TX, USA

 

Thomas G.H. Diekwisch, D.M.D., Ph.D. (sc.), Ph.D. (phil.), was born in Bielefeld, Germany.  Diekwisch holds degrees in dental medicine (1986, D.M.D.), anatomy (1988, Ph.D. with "summa cum laude") and philosophy (2005, Ph.D. with “magna cum laude”), all from the Philipps-University of Marburg/Germany.  From 1986-1990, Diekwisch worked as a lecturer, clinical instructor and research associate in the Departments of Anatomy and Periodontics at the Philipps-University.  After postdoctoral training at the University of Southern California, he joined the faculty of Baylor College of Dentistry in Dallas/TX in 1994.  In 2001, Diekwisch was recruited to the University of Illinois at Chicago to become the first Director of the Brodie Laboratory for Craniofacial Genetics and the Allan G. Brodie Endowed Chair for Orthodontic Research.  Two years later, he was appointed Professor and Head of the Department of Oral Biology.  In 2009, he became an honorary professor at Jilin University in Changchun, China.  In 2014, Diekwisch returned to Texas A&M University College of Dentistry as the Director of the Center for Craniofacial Research and Diagnosis (CCRD) and the Head of the Department of Periodontics.  In 2017, Diekwisch became the first holder of the Bernhard Gottlieb Endowed Chair in Craniofacial Research.  Diekwisch’s team is interested in tissue engineering, epigenetics, enamel and periodontal research. 

 

Richards_R_Geoff

eCM Guest Editor

Dr Luan
Center for Craniofacial Research and Diagnosis (CCRD) and Department of Periodontics, Texas A&M University College of Dentistry, TX, USA

 

Xianghong Luan was originally trained as an MD and arrived in the United States in 1994.  From 1994-1998, she worked as postdoctoral fellow at the University of Texas Health Sciences Center at San Antonio, first in the Department of Medicine and then in the Department of Pediatric Dentistry.  From 1998 until 2001, Dr. Luan worked at Baylor College of Dentistry in Dallas/TX as a Research Assistant Professor focusing on questions related to craniofacial genetics.  In 2001, Dr. Luan moved to the University of Illinois at Chicago, first as an Assistant Professor.  At UIC began to focus her research on stem cells and tissue regeneration.  She was promoted to the rank of Associate Professor in 2009.  In 2018, Dr. Luan was recruited as a Professor and Director of Research in the Department of Periodontics at Texas A&M College of Dentistry.  At Texas A&M, Dr. Luan shifted the focus of her research to microRNAs in periodontal regeneration and temporo-mandibular joint research.  In her role as Director of research, she oversees the translational aspects of the Periodontics research program.

 

Richards_R_Geoff

eCM Guest Editor

Associate Prof. David A. Reed
Department of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago, IL, USA

 

David A. Reed is an Associate Professor of Oral Biology at the University of Illinois Chicago College of Dentistry. He has a PhD in Integrative Biology from the University of Chicago, and he completed post-doctoral training at the University of Illinois Chicago with research interests in biomineralization and tissue engineering in the orofacial skeleton. His current research focuses on defining how mandibular fibrochondrocytes interact with the extracellular matrix during TMJ health and disease, including how injury and mechanical overloading induces 1) cellular autophagy/apoptosis, 2) fibrogenic remodeling of the extracellular matrix, and 3) progenitor cell migration. He was awarded the Clinical and Translational Science Mentored Career Development Grant from the National Center for Advancing Translational Sciences for his work on TMJ dysfunction. His laboratory is supported by National Institutes of Health and the Oral and Maxillofacial Surgery Foundation. He is a member of the editorial review board for Nature Scientific Reports.

Submit now